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1.
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc Natl Acad Sci U S A;
121(1): e2310727120, 2024 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38150499
2.
Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo.
PLoS Pathog;
19(10): e1011496, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37871122
3.
Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
J Virol;
97(11): e0144823, 2023 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37855638
4.
A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation.
J Biol Chem;
298(8): 102248, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35820485
5.
Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy.
Basic Res Cardiol;
112(4): 37, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28526910
6.
The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
Biochem Biophys Res Commun;
475(1): 64-9, 2016 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-27169767
7.
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.
J Biol Chem;
289(7): 4219-32, 2014 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24371145
8.
TARGETING SOLUBLE AMYLOID-BETA OLIGOMERS WITH A NOVEL NANOBODY.
Res Sq;
2024 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38559050
9.
Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.
J Biol Chem;
287(29): 24207-15, 2012 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22613722
10.
Protein phosphatase 2A family members (PP2A and PP6) associate with U1 snRNP and the spliceosome during pre-mRNA splicing.
Biochem Biophys Res Commun;
440(2): 306-11, 2013 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24064353
11.
Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme.
bioRxiv;
2023 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37066309
12.
The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.
J Biol Chem;
286(20): 17665-71, 2011 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21454489
13.
Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle.
J Biol Chem;
286(10): 8043-8054, 2011 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21193409
14.
Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress.
Mol Cell Endocrinol;
557: 111754, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35987388
15.
Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer's Disease.
Pharmaceuticals (Basel);
15(6)2022 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35745661
16.
Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis.
J Biol Chem;
285(18): 13827-38, 2010 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-20220139
17.
Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.
Biochemistry;
49(8): 1713-8, 2010 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-20092282
18.
PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation.
Cell Rep;
30(9): 3171-3182.e6, 2020 03 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32130916
19.
Role of protein phosphatase 2A in regulating the visual signaling in Drosophila.
J Neurosci;
28(6): 1444-51, 2008 Feb 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-18256265
20.
Targeting protein serine/threonine phosphatases for drug development.
Mol Pharmacol;
75(6): 1249-61, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19299564